Selective exosite inhibition of PAPP-A activity against IGFBP-4

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专利权人:

オーフス ユニバーシテ

发明人:

オクスビグ クラウス,ミッケルセン ヤコブ ホーグ,ニールセン クラウス ギラップ

申请号：

JP2010543511

公开号：

JP5727792B2

申请日:

2009.01.23

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting.

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中国工程科技知识中心

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http://www.ckcest.cn/home/