GUTIERREZ, GABRIEL M.,KOTRAIAH, VINAYAKA,PHARES, TIMOTHY,PANNUCCI, JAMES
申请号：
CA3064023
公开号：
CA3064023A1
申请日:
2018.05.25
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
This disclosure provides peptides which have a strong affinity for thecheckpoint receptor "programmed death 1" (PD-1).These peptides block the interaction of PD-1 with its ligand PD-L1 as well asthe interaction of CTLA4 with CD86 and can thereforebe used for various therapeutic purposes, such as inhibiting the progressionof a hyperproliferative disorder, including cancer； treatinginfectious diseases； enhancing a response to vaccination； treating sepsis； andpromoting hair re-pigmentation or lightening of pigmentedskin lesions.
