Gabriel M. Gutierrez,Vinayaka Kotraiah,Timothy W. Phares,James Pannucci
申请号：
US15989750
公开号：
US20180339044A1
申请日:
2018.05.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer； treating infectious diseases； enhancing a response to vaccination； treating sepsis； and promoting hair re-pigmentation or lightening of pigmented skin lesions.
