Gutierrez, Gabriel M.,Kotraiah, Vinayaka,Phares, Timothy,Pannucci, James
申请号：
AU2018273958
公开号：
AU2018273958A1
申请日:
2018.05.25
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer； treating infectious diseases； enhancing a response to vaccination； treating sepsis； and promoting hair re-pigmentation or lightening of pigmented skin lesions.
