Venita I. DeAlmeida;James A. Ernst;Paul Polakis;Bonnee Rubinfeld
发明人:
James A. Ernst,Paul Polakis,Bonnee Rubinfeld,Venita I. DeAlmeida
申请号：
US13367760
公开号：
US20120141481A1
申请日:
2012.02.07
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
