Jeffrey S. Rubin,Aykut Üren,Susan Cumberledge,Frieda Reichsman
申请号：
US13031060
公开号：
US08158603B2
申请日:
2011.02.18
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention stems from the discovery that sFRP and fragments thereof can bind to members of the Wnt family of proteins and cause an increase in Wnt biological activity. Furthermore, fragments of sFRP that do not contain the CRD domain are shown to bind to Wnt proteins and modulate Wnt biological activity. Accordingly, the invention provides these sFRP fragments and variants of these fragments, as well as vectors and host cells containing nucleic acid sequences encoding the sFRP fragments and variants.
