James A. ERNST,Paul POLAKIS,Bonnee RUBINFELD,Venita I. DEALMEIDA
申请号：
US15385528
公开号：
US20170349639A1
申请日:
2016.12.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.
