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LITHIUM SALTS OF AMINOSULPHONYL-CHLORO-PHENOXYACETIC ACIDS AND PROCESS FOR PREPARING THE SAME
专利权人:
STEFANACHE ALINA
发明人:
STEFANACHE ALINA,STEFANACHE ALINA,ONISCU CORNELIU,ONISCU CORNELIU
申请号:
RO201400489
公开号:
RO130736A2
申请日:
2014.06.25
申请国别(地区):
RO
年份:
2015
代理人:
摘要:
The invention relates to a process for preparing the lithium salts of aminosulphonyl-chloro-phenoxyacetic acids, salts used as medicaments with antidepressive action. According to the invention, the process comprises the reaction between the solution of the aminosulphonyl-chloro-phenoxyacetic acids and the solution of lithium hydroxide in methanol, which is performed while stirring, in a volume ratio of 3:1, at a temperature of 20...40°C, for 2...8h, then the reaction mass is cooled down to 10...15°C, is filtered and washed, on the filter, with ethanol and acetone and is dried at the temperature of 30...32°C.Invenţia se referă la un procedeu de obţinere a sărurilor de litiu ale acizilor aminosulfonil-cloro-fenoxiacetici, săruri utilizate ca medicamente cu acţiune antidepresivă. Procedeul conform invenţiei constă în reacţia dintre soluţia acizilor aminosulfonil-cloro-fenoxiacetici cu soluţia de hidroxid de litiu în metanol, care se realizează sub agitare, într-un raport volumetric de 3:1, la o temperatură de 20...40°C, timp de 2...8 h, după care masa de reacţie se răceşte la 10...15°C, se filtrează, se spală pe filtru cu alcool etilic şi acetonă, şi se usucă la temperatura de 30...32°C.
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中国工程科技知识中心
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