It possesses the meaning, as for this invention, the pyrazine derivative formula (i) or that the salt which can be allowed medicine (n in formula, as for m and R gap which we would like to decide in the respective bill whether of) Those production manners, it regards those uses in producing the medicine in order to use for the medicine constituent, and bone-related fault or the disposal of state which contain those.< Choice figure >It is not本発明は、式(I)のピラジン誘導体またはその医薬的に許容できる塩(式中のn、mおよびRはそれぞれ明細書中に定めたいずれかの意味を有する);それらの製造方法、それらを含有する医薬組成物、および骨関連の障害または状態の処置に使用するための医薬の製造におけるそれらの使用に関する。【選択図】なし