methods for inducing fviii immune tolerance, for making a fviii peptide, and for identifying a fvii peptide specific t cell, peptide, composition, and fusion protein
BIRGIT MARIA REIPERT,HANS-PETER SCHWARZ,HARTMUT EHRLICH,KATHARINA NORA STEINITZ,PAULA MARIA WILHELMINA VAN HELDEN
申请号：
BR112013010362
公开号：
BR112013010362A2
申请日:
2011.10.27
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e. g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII-specific CD4 + T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.
