INHIBITEURS DE L'HISTONE DEMETHYLASE-1 SPECIFIQUES DE LA LYSINE ET LEURS UTILISATIONS

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专利权人:

UNIVERSITY OF CANBERRA

发明人:

RAO, SUDHA,MILBURN, PETER

申请号：

CA3035806

公开号：

CA3035806A1

申请日:

2017.09.07

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

Disclosed are lysine specific histone demethylase-1 (LSD1) inhibitors in methods and compositions for immune checkpoint inhibition. The invention also relates to proteinaceous molecules and their use in altering at least one of (i) formation, (ii) 5 proliferation, (iii) maintenance, (iv) epithelial to mesenchymal cell transition (EMT), or (v) mesenchymal to epithelial cell transition (MET) of an LSD1 overexpressing cell.

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