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COMPOSÉ PHÉNYL TÉTRAHYDROISOQUINOLÉINE SUBSTITUÉ PAR UN HÉTÉROARYLE
专利权人:
Taisho Pharmaceutical Co.; Ltd.
发明人:
申请号:
EP15825310.4
公开号:
EP3173408A1
申请日:
2015.07.24
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3 inhibitory effect:        [Formula 15]     A-Y [1]whereinA represents a structure represented by the following formula [2]:whereinR11 and R12 each represent a halogen atom or the like,R2 represents C1-6 alkyl or the like,ring E represents triazole, tetrazole, pyrimidine, or the like,R31 and R32 each represent a hydrogen atom, C1-6 alkyl, C1-6 alkoxy, or the like, andW represents a single bond, the formula -NH-, the formula -O-, or the formula -CONH-, andY represents a hydrogen atom or a structure represented by the following formula [3']:
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