Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP) are described herein. Exemplary disorders include schizophrenia and cognitive deficit.本文中描述了使用化合物治療失調的方法,所述化合物調節富含紋狀體的酪胺酸磷酸酶(STEP)。示範性的失調包含精神分裂症以及認知缺陷。