Methods of treating disorders using compounds that modulate striatal-enriched tyrosine phosphatase (STEP) are described herein. Exemplary disorders include schizophrenia and cognitive deficit.此處係揭露使用調節富紋狀體(Striatal)之酪氨酸磷酸酶(STEP)之化合物治療異常之方法。例示之異常包括精神分裂症及認知不足。