The present invention provides certain 3,4- dihydro-isoquinolines -2 (1H)-based compound, the especially compound and its pharmaceutical composition of formula (I). Invention further provides the methods for using the compound of formula (I) to treat cognitive impairment relevant to Parkinson's disease or schizophrenia.本發明提供了某些3,4-二氫異喹啉-2(1H)-基化合物,特別是式(I)的化合物,及其藥物組合物。本發明進一步提供了使用式(I)的化合物以治療與帕金森氏病或精神分裂症相關的認知損害的方法。