The present invention provides available what treatment bipolar disorders, the new mGlu2 agonists of schizophrenia, depression and generalized anxiety disorder. The new agonist is indicated by formula.本發明提供了可用於治療雙相性精神障礙、精神分裂症、抑鬱和廣泛性焦慮症的新的mGlu2激動劑。該新的激動劑通過式子表示。