JUN ZHANG,NINGSHAO XIA,SHAOWEI LI,SHENGXIANG GE,YING GU,ZHIQIANG HE
申请号：
BR122015016384
公开号：
BR122015016384B1
申请日:
2002.11.08
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Summary "recombinant or isolated polypeptide, nucleic acid molecule, diagnostic kit for detecting hepatitis e infection, vaccine composition, pharmaceutical composition, recombinant expression vector, transformed host cell and use of recombinant or isolated polypeptide" herein The invention relates to the monoclonal antibody specifically linked to the polypeptide (s) comprising the amino acid sequence as represented in sequence: hepatitis virus orf2 and or conserved variants or active fragments thereof, or other monoclonal antibodies against orf2 which may cross-react with said monoclonal antibody of the present invention, and its degraded nucleotide sequence or sequence； for the antigenic determinant in hepatitis virus orf2 and； for a method for classifying isolated or recombined polypeptide or peptide analogue, which has the same property of specifically binding to said 8c11 and / or 8h3 monoclonal antibody as said hepatitis virus orf2 antigenic determinant 1) or 3) and； for polypeptide or peptide analog classified by the above method and its nucleotide sequence or degenerate sequence thereof； for use of said polypeptide or polypeptide analog in the preparation of a medicament for the diagnosis and / or prevention of hepatitis virus infection and； for a hepatitis virus infection diagnostic kit and and a vaccine composition for hepatitis virus infection prophylaxis e； for using said monoclonal antibodies or conserved active fragments or variants thereof in the preparation of a medicament for the diagnosis, prophylaxis and / or treatment of hepatitis virus infection and； for pharmaceutical composition for prophylaxis and / or treatment of hepatitis virus infection and and a method for prophylaxis and / or treatment of hepatitis virus infection e； for a recombinant expression vector comprising said nucleotide molecule in the present invention and a host cell transformed with said recombinant expression vector which is capable of expressing the monoclonal antibody and
