antibody or fragment thereof, nucleic acid molecule, use of monoclonal antibody or fragment thereof, diagnostic kit, pharmaceutical composition, recombinant expression vector, host cell transformed with recombinant expression vector and method for detecting antigen virus hepatitis and or the hepatitis virus antibody and in a sample
JUN ZHANG,NINGSHAO XIA,SHAOWEI LI,SHENGXIANG GE,YING GU,ZHIQIANG HE
申请号：
BR0214188
公开号：
BRPI0214188B1
申请日:
2002.11.08
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
"monoclonal antibodies against hepatitis virus and / or fragments thereof with binding activity and use". The present invention relates to the monoclonal antibody specifically linked to the polypeptide (s) comprising the amino acid sequence as represented in hepatitis virus orf2 sequence and or conserved variants thereof or active fragments thereof. or other monoclonal antibodies against orf2 which may be cross-reactive with said monoclonal antibody of the present invention, and its degraded nucleotide sequence or sequence； for the antigenic determinant in hepatitis virus orf2 and； for a method for classifying isolated or recombined polypeptide or peptide analogue, which has the same property of specifically binding to said 8c11 and / or 8h3 monoclonal antibody as said hepatitis virus orf2 antigenic determinant 1) or 3) and； for polypeptide or peptide analog classified by the above method and its nucleotide sequence or degenerate sequence thereof； for use of said polypeptide or polypeptide analog in the preparation of a medicament for the diagnosis and / or prevention of hepatitis virus infection and； for a hepatitis virus infection diagnostic kit and and a vaccine composition for hepatitis virus infection prophylaxis e； for using said monoclonal antibodies or conserved active fragments or variants thereof in the preparation of a medicament for the diagnosis, prophylaxis and / or treatment of hepatitis virus infection and； for pharmaceutical composition for prophylaxis and / or treatment of hepatitis virus infection and and a method for prophylaxis and / or treatment of hepatitis virus infection e； for a recombinant expression vector comprising said nucleotide molecule in the present invention and a host cell transformed with said recombinant expression vector which is capable of expressing the monoclonal antibody and conserved variants thereof or active fragments or polypeptides or polypeptide analogs."anticorpos monoclonais contra o vírus da hepatite e ou seus fra
