GHAYUR, TARIQ,SALFELD, JOCHEM G.,MCPHERSON, MICHAEL J.,HARRIS, MARIA C.,LIU, JUNJIAN,ISAKSON, PETER C.,GU, JIJIE
申请号：
PE0005672012
公开号：
PE15432012A1
申请日:
2010.10.28
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a Binding Protein that comprises: a) a First polypeptide Chain: VD1 and VD2 (x1) n - (N - (x2), where VD1 and VD2 are respectively a First and second variable domain of the heavy chain, with an Amino Acid Sequence SEQ ID: we selected 28 30, 32, 34, 36, 38, 40, 42 And 44 c is a constant domain of the heavy chain.X1 is a connector on the condition that he not be CH1 x2 is a selected FC region of IgG1, IgG2, IgG3, IgG4, IgE and IgA, IgM, IgD and (b) a Second polypeptide Chain: VD1 and VD2 (x1) n - (N - (x2), where VD1 and VD2 respectively a First and second variable domain of the light chain, with a s Ecuencia amino acid SEQ ID: we selected 29, 31, 33, 35, 37, 39, 41, 43,And 45, C is a constant domain of the light chain x1 is a Connector with the condition that they not be CH1 (x2) n does not include an FC region x1 or x2 is selected from an Amino Acid Sequence SEQ ID: 1 - 26 where such Binding Protein has the ability of joining a pair of D Antigen The Group consists of TNF (SEQ. 2) and NGF TNF (SEQ. 2) and a support (seq.2) TNF and PGE2, TNF (SEQ.1) and LPA among others. Also refers to a conjugated Protein, Nucleic Acid, vector, host Cell, production method, and a Pharmaceutical composition. This Binding Protein is useful for the treatment of thyroiditis, Asthma, dermatitis, Parkinsons disease, arthropathySE REFIERE A UNA PROTEINA DE UNION QUE COMPRENDE: A) UNA PRIMERA CADENA DE POLIPEPTIDOS: VD1-(X1)n-VD2-C-(X2)n, DONDE VD1 Y VD2 RESPECTIVAMENTE SON UN PRIMER Y SEGUNDO DOMINIO VARIABLE DE LA CADENA PESADA, CON UNA SECUENCIA DE AMINOACIDOS SELECCIONADAS DE SEQ ID NOs: 28, 30, 32, 34, 36, 38, 40, 42 Y 44 C ES UN DOMINIO CONSTANTE DE LA CADENA PESADA, X1 ES UN CONECTOR CON LA CONDICION QUE NO SEA CH1 X2 ES UNA REGION Fc SELECCIONADA DE IgG1, IgG2, IgG3, IgG4, IgA, IgM, IgE E IgD Y B) UNA SEGUNDA CADENA DE POLIPEPTIDOS: VD1-(X1)n-VD2-C-(X2)n, DONDE VD1 Y VD2 RESPECTIVAMENTE SON UN PRIMER Y SEGUNDO DOMINIO VARIABLE DE LA CADENA LIVIANA, CON UNA SECUENCIA DE AMIN
