GHAYUR, TARIQ,KAMATH, RAJESH V.,LIU, JUNJIAN,HONORE, MARIE P.
申请号：
PE0004672012
公开号：
PE15312012A1
申请日:
2010.10.15
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Refers to a Binding Protein comprising a First polypeptide Chain: VD1 and VD2 (x1) n - (N - (x2), where VD1 and VD2 are respectively a First and second variable domain of the heavy chain, with an Amino Acid Sequence SEQ ID Nos: 28, 30, 32 and 34 c is a domain of Constant Heavy chain,X1 is a Connector with the condition that they not be CH1 x2 is a selected FC region of IgG1, IgG2, IgG3, IgG4, IgE and IgA, IgM, IgD and (b) a Second polypeptide Chain: VD1 and VD2 (x1) n - (N - (x2), where VD1 and VD2 respectively a First and second variable domain of the light chain, with a Amino Acid Sequence of SEQ ID Nos: 29, 31,33 and 35, C is a constant domain of the light chain x1 is a Connector with the condition that they not be CH1 x2 is not a FC region n is 0 OR 1 x1 or x2 is selected from an Amino Acid Sequence SEQ ID: 1 - 26 where such Binding Protein it is able to bind a pair of antigens Group formed by NGF and NGF and PGE2, TNF alpha and il-1beta, NGF and NGF, il-6r.Also refers to a conjugated Protein, Nucleic Acid, vector, host Cell, production method, and a Pharmaceutical composition. This Binding Protein is useful for the treatment of chronic Active hepatitis, rheumatoid arthritis, psoriasis, dermatitisSE REFIERE A UNA PROTEINA DE UNION QUE COMPRENDE A) UNA PRIMERA CADENA POLIPEPTIDICA: VD1-(X1)n-VD2-C-(X2)n, DONDE VD1 Y VD2 RESPECTIVAMENTE SON UN PRIMER Y SEGUNDO DOMINIO VARIABLE DE LA CADENA PESADA, CON UNA SECUENCIA DE AMINOACIDOS DE SEQ ID NOs: 28, 30, 32 Y 34 C ES UN DOMINIO CONSTANTE DE LA CADENA PESADA, X1 ES UN CONECTOR CON LA CONDICION DE QUE NO SEA CH1 X2 ES UNA REGION Fc SELECCIONADA DE IgG1, IgG2, IgG3, IgG4, IgA, IgM, IgE Y IgD Y B) UNA SEGUNDA CADENA POLIPEPTIDICA: VD1-(X1)n-VD2-C-(X2)n, DONDE VD1 Y VD2 RESPECTIVAMENTE SON UN PRIMER Y SEGUNDO DOMINIO VARIABLE DE LA CADENA LIVIANA, CON UNA SECUENCIA DE AMINOACIDOS DE SEQ ID NOs: 29, 31, 33 Y 35 C ES UN DOMINIO CONSTANTE DE LA CADENA LIVIANA X1 ES UN CONECTOR CON LA CONDICION DE QUE NO SEA CH1 X2 NO COMPRE
