GHAYUR TARIQ,SALFELD JOCHEN G.,MPHERSON MICHAEL J.
申请号：
ARP110103124
公开号：
AR082739A1
申请日:
2011.08.26
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
Multivalent binding proteins and Methods for producing modified multi species, and, specifically, its use in the Prevention, diagnosis and / or treatment of diseases.Claim 1: a Binding Protein that has the ability to bind to two antigens and comprising a First and a Second polypeptide Chain, wherein the first polypeptide Chain comprises a First VD1 and VD2 (x1) n - (N - (x2)Where VD1 is a First variable domain of the heavy chain； VD2 is a Second variable domain of the heavy chain, C is a constant domain of the heavy chain； x1 is a Connector with the condition not CH1； x2 is an FC region； and where the second polypeptide Chain comprising A Second VD1 and VD2 (x1) n - (N - (x2)Where VD1 is a First variable domain of the light chain； VD2 is a Second variable domain of the light chain, C is a constant domain of the light chain is a Connector； x1； x2 is not a FC region； and where n is 0 OR 1； and where the Union can Protein join TNF And NGF and SOST； TNF； TNF and TNF and PGE2； LPA； where X1 is: (a)Between the first and second variable domain of the heavy chain, and astkgp X1 is between the first and second variable domain of the light chain, tvaapsvfifpp； (b) x1 is between the first and second variable domain of the heavy chain, and astkgpsvfplap X1 is between the first and second domi Nio tvaap light chain variable, X1 is； or (c),Between the first and second variable domain of the heavy chain, and astkgpsvfplap X1 is between the first and second variable domain of the light chain, tvaapsvfifpp.Proteínas de unión multivalentes y multiespecíficas modificadas, métodos para elaborarlas y, específicamente, sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.Reivindicación 1: Una proteína de unión que tiene la capacidad de unirse a dos antígenos y que comprende una primera y una segunda cadena de polipéptidos, caracterizada porque dicha primera cadena de polipéptidos comprende un primer VD1-(X1)n-VD2-C-(X2)n, en donde VD1 es un primer dominio variabl
