PROBLEM TO BE SOLVED: To provide a solid pharmaceutical formulation containing ranitidine that controls discoloration of the ranitidine, and a method for producing a ranitidine-supporting particle to be blended with the formulation.SOLUTION: The solid pharmaceutical formulation containing ranitidine is characterized in that it has acid-controlling power larger than 200 mL which is determined by the acid-controlling power testing method according to the fifteenth Revision of Japanese Pharmacopoeia and that it contains the ranitidine-supporting particle which supports the ranitidine on an inorganic compound containing magnesium and/or calcium having a magnesium and/or calcium content of 20 mass% or higher.COPYRIGHT: (C)2010,JPO&INPIT【課題】ラニチジンの変色が抑制されたラニチジン含有医薬固形製剤、及び製剤に配合するラニチジン担持粒子の製造方法を提供する。【解決手段】第十五改正日本薬局方の制酸力試験法によって求められる制酸力が200mLを超え、かつマグネシウム及び/又はカルシウム含有量が20質量%以上であるマグネシウム及び/又はカルシウム含有無機化合物に、ラニチジンを担持させたラニチジン担持粒子を含有することを特徴とするラニチジン含有医薬固形製剤。【選択図】図1
