LIMONOV;ЛИМОНОВ, Виктор Львович;LIMONOV, Viktor Lvovich; Viktor Lvovich
发明人:
GAIDUL, Konstantin Valentinovich,ГАЙДУЛЬ, Константин Валентинович,DUSHKIN, Aleksandr Valerevich,ДУШКИН, Александр Валерьевич
申请号：
RURU2011/000320
公开号：
WO2012/036585A1
申请日:
2011.05.11
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
The invention relates to pharmacology, medicine, veterinary medicine and to the pharmaceutical industry, in particular to a process for preparing original composite antimicrobial preparations for parenteral administration which have increased therapeutic effectiveness in the treatment of severe forms of infectious and inflammatory diseases. The proposed pharmaceutical compositions comprise, as active ingredient, beta-lactam antibiotics and highly disperse nanostructured silicon dioxide in ratios of from 10:1 to 75:1 by weight, respectively. The silicon dioxide particles present in the composition are the means of supplying the molecules of the antibiotics to the phagocytes, which makes it possible to increase, in a targeted manner, the concentration of the antimicrobial preparations in the areas of inflammation and to substantially neutralize the phenomenon of antibiotic resistance of microorganisms. The claimed process for preparing a pharmaceutical composition consists in mixing a beta-lactam antibiotic substance with highly disperse nanostructured silicon dioxide and is characterized in that the mixture of the above-mentioned substances in ratios of from 10:1 to 75:1 by weight, respectively, is subjected to mechanical processing by means of impact abrasion until the proportion by weight of the finely disperse fraction (<； 5 µm) is increased to at least 25%. The resultant mixture is used for preparing injection solutions.L'invention se rapporte au domaine de la pharmacologie, de la médecine, de la médecine vétérinaire et de l'industrie pharmaceutique, et concerne notamment un procédé de production de préparation antimicrobiennes complexes originales pour administration parentérale, qui possèdent une efficacité thérapeutique accrue lors du traitement de formes lourdes de maladies infectieuses et inflammatoires. Ces compositions pharmaceutiques comprennent contiennent en qualité de substance active des antibiotiques bêta-lactames et du dioxyde de silicium à haute
