Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS)
发明人:
WU, Yin,ZEN, Hairong,LIU, Xin
申请号：
EP20170910501
公开号：
EP3521815(A4)
申请日:
2017.12.29
申请国别(地区):
欧洲专利局
年份:
2019
代理人:
摘要：
Provided is a method for measuring pH. Using amide protons as an endogenous contrast agent, a chemical exchange saturation transfer effect ratio R of amide protons corresponding to a pH-known amide proton solution under different saturation powers is measured by the method, then a function relation between pH and R is established according to different pH-known amide proton solutions and the corresponding measured R thereto, and finally the desired pH is calculated according to experimentally measured Rand the function relation. The method can eliminate the impact of concentration and does not require any estimation or measurement of the parameters such as the concentration of exchangeable protons, the longitudinal relaxation time of water, etc., and therefore can measure pH more accurately, conveniently and non-invasively. In addition, amide groups have a relatively low chemical exchange rate, and can be imaged stably under a clinical magnetic field strength, promising for clinical practices.
