ANDERSON, ROBERT PAUL,STEWART, JESSICA ANNE,DROMEY, JAMES ANTHONY,TYE-DIN, JASON ALLAN
申请号：
ES09828453
公开号：
ES2549481T3
申请日:
2009.11.30
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A composition comprising i) a first peptide comprising the amino acid sequence: LQPFPQPELPYPQPQ (SEQ ID NO: 13), a biologically active fragment thereof of not less than 7 amino acids in length and capable of generating a T lymphocyte response in a subject sensitive to gluten equal to or greater than the peptide from which it is derived, or a biologically active variant thereof that has no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating a T-lymphocyte response in a subject sensitive to gluten equal to or greater than the peptide from which it is derived, ii) a second peptide comprising the amino acid sequence: QPFPQPEQPFPWQP (SEQ ID NO: 14), a biologically active fragment thereof of not less than 7 amino acids in length and capable of generating a T-lymphocyte response in a gluten sensitive subject equal to or greater than the peptide from which it is derived, or a biologically active variant thereof that has no more of 3 amino acid variations compared to the peptide from which it is derived and capable of generating a T-lymphocyte response in a gluten sensitive subject equal to or greater than the peptide from which it is derived, and iii) a third peptide comprising the amino acid sequence : PEQPIPEQPQPYPQQ (SEQ ID NO: 16), a biologically active fragment thereof of not less than 7 amino acids in length and capable of generating a T-lymphocyte response in a gluten sensitive subject equal to or greater than the peptide from which it is derived, or a biologically active variant thereof that has no more than 3 amino acid variations compared to the peptide from which it is derived and capable of generating a T-lymphocyte response in a gluten sensitive subject equal to or greater than the peptide from which it is derived.Una composición que comprende i) un primer péptido que comprende la secuencia de aminoácidos: LQPFPQPELPYPQPQ (SEC ID Nº: 13), un fragmento biológicamente activo del mismo de no menos de 7 amino
