ANTIBODY-BASED THERAPEUTICS WITH ENHANCED ADCC ACTIVITY

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专利权人:

GENZYME CORPORATION

发明人:

MCPHERSON JOHN M.,EDMUNDS TIM,ZHOU QUN

申请号：

SI200631261

公开号：

SI1945665T1

申请日:

2006.10.20

申请国别(地区):

SI

年份:

2012

代理人:

摘要：

Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/