Sass, Philip M.,Nicolaides, Nicholas,Grasso, Luigi,Routhier, Eric,Gu, Wei,Young, Jason,Yao, Jun
申请号：
AU2016202082
公开号：
AU2016202082A1
申请日:
2016.04.04
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016202082A120160428.pdf#####ABSTRACT The invention provides anti-FRA antibodies with novel N-linked neutral glycan profiles in that the relative amounts of one or more neutral glycans are increased or decreased compared to anti-FRA antibodies produced under reference cell culture conditions. The invention further provides anti-FRA antibodies with altered binding to FRA, altered antibody-dependent cellular cytotoxicity (ADCC) and/or altered rate and/or efficiency of internalization in a cell expressing FRA. In related aspects, the invention provides cell cultures comprising an anti-FRA antibody of the invention, a cell isolated from such a culture, kits and compositions comprising an antiFRA antibody of the invention, methods of producing an anti-FRA antibody of the invention and diagnostic and therapeutic uses of an anti-FRA antibody of the invention.
