Sass, Philip M.,Nicolaides, Nicholas,Grasso, Luigi,Routhier, Eric,Gu, Wei,Young, Jason,Yao, Jun
申请号：
AU2011317088
公开号：
AU2011317088A1
申请日:
2011.10.19
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The invention provides anti-FRA antibodies with novel N-linked neutral glycan profiles in that the relative amounts of one or more neutral glycans are increased or decreased compared to anti- FRA antibodies produced under reference cell culture conditions. The invention further provides anti-FRA antibodies with altered binding to FRA, altered antibody-dependent cellular cytotoxicity (ADCC) and/or altered rate and/or efficiency of internalization in a cell expressing FRA. In related aspects, the invention provides cell cultures comprising an anti-FRA antibody of the invention, a cell isolated from such a culture, kits and compositions comprising an anti-FRA antibody of the invention, methods of producing an anti-FRA antibody of the invention and diagnostic and therapeutic uses of an anti-FRA antibody of the invention.
