Disclosed is a powder composition of mannitol crystals, produced by: (i) the crystallization of mannitol in a solvent； followed by (ii) a step of separating the crystals from the resulting crystal suspension； (iii) a step of drying the crystals； and (iv) a selection step, the composition having a particle size distribution, as determined by laser particle sizing, of 72 to 99.9 vol % of particles having a particle size greater than 75 &mu；m, of 0.1 to 60 vol % of particles larger than 250 &mu；m, and a mean diameter of between 100 and 300 &mu；m. Also described is a method for producing such a composition by a step of crystallizing a mannitol syrup followed by drying the mannitol crystals, a step of selecting particles, and a step of collecting a fraction of the powder composition including 72 to 99.9% of particles having a particle size greater than 75 &mu；m.
