FORME PHARMACEUTIQUE MULTIPARTICULAIRE CONTENANT DES PRINCIPES ACTIFS PEPTIDIQUES OU PROTEIQUES FORMULES DE FACON A PRESENTER UNE ACTION MUCOADHESIVE, ET METHODE DE PRODUCTION DE CETTE FORME PHARMACEUTIQUE
LIZIO, ROSARIO,PETEREIT, HANS-ULRICH,ROTH, ERNA,DE ANDRES, INES,DAMM, MICHAEL
申请号：
CA2532487
公开号：
CA2532487C
申请日:
2004.07.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention relates to an oral, multiparticlepharmaceutical dosage form containing pellets, the sizeof which ranges from 50 to 2500 m and which essentiallyconsist of: a) an inner matrix layer containing anactive substance which is a peptide or a protein,including the derivatives or conjugates thereof, andwhich is embedded in a matrix consisting of a polymerwith mucoadhesive effect, and b) an outer film coatingessentially consisting of an anionic polymer orcopolymer, which can be optionally formulated withpharmaceutically conventional adjuvants, moreparticularly softening agents.
