ANTIBODY BEING CAPABLE OF BINDING TO TRANSFORMING GROWTH FACTOR ALPHA AND HAVING GROWTH-SUPPRESSING ACTIVITY ON CANCERS HAVING Ras GENE MUTATION

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专利权人:

发明人:

KANEDA MAKOTO,FUJII YOSHIHIRO,HAYATA YOSHIHIRO,KISHI YOSHIRO,YAHARA ICHIRO

申请号：

IN10016/DELNP/2012

公开号：

IN2012DN10016A

申请日:

2012.11.19

申请国别(地区):

IN

年份:

2014

代理人:

摘要：

It has been found out that among antibodies showing reactivity with wild type TGF-α antibodies less reactive with G79A-substituted TGF-α have an excellent growth-suppressing effect on cancer cells having a mutated Ras gene. Further it has been found out that most of these antibodies have an activity of inhibiting EGFR tyrosine phosphorylation and/or an induction-suppressing activity on vascular endothelial cells.

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中国工程科技知识中心

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http://www.ckcest.cn/home/