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ANTIBODY CAPABLE OF BINDING TO TRANSFORMING GROWTH FACTOR ALPHA AND HAVING ANTIPROLIFERATIVE ACTIVITY ON CANCER HAVING Ras GENE MUTATION
专利权人:
MEDICAL AND BIOLOGICAL LABORATORIES CO.; LTD.
发明人:
KANEDA MAKOTO,FUJII YOSHIHIRO,HAYATA YOSHIHIRO,KISHI YOSHIRO,YAHARA ICHIRO
申请号:
EP11783563
公开号:
EP2573175A4
申请日:
2011.05.17
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
It has been found out that among antibodies showing reactivity with wild type TGF-±, antibodies less reactive with G79A-substituted TGF-± have an excellent growth-suppressing effect on cancer cells having a mutated Ras gene. Further, it has been found out that most of these antibodies have an activity of inhibiting EGFR tyrosine phosphorylation and/or an induction-suppressing activity on vascular endothelial cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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