Jack R. Wands,Suzanne De La Monte,Arihiro Aihara,Mark Jon Olsen,John-Michael Thomas
申请号：
US15715989
公开号：
US10710995B2
申请日:
2017.09.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
