WANDS, JACK R.,DE LA MONTE, SUZANNE,AIHARA, ARIHIRO,OLSEN, MARK JON,THOMAS, JOHN-MICHAEL
申请号：
CA2885762
公开号：
CA2885762A1
申请日:
2013.09.20
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2- heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
