WANDS, JACK, R. JR,DE LA MONTE, SUZANNE S,AIHARA, ARIHIRO A,OLSEN, MARK, JON MJ,THOMAS, JOHN-MICHAEL J-M,.萬茲,.德拉蒙特,.相原,.奧爾森,.托馬斯
申请号：
HK15109523.0
公开号：
HK1208805A
申请日:
2015.09.29
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
