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Combined Preparations of PKM2 Modulators and HMGB1
专利权人:
Ruprecht-Karls-Universität Heidelberg
发明人:
Georg Gdynia,Wilfried Roth
申请号:
US16061300
公开号:
US20200289560A1
申请日:
2016.12.12
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to a combined preparation comprising (i) a modulator of pyruvate kinase M2 (PKM2) activity, and (ii) an agent providing high mobility group box 1 (HMGB1) polypeptide or a derivative thereof. The present invention also relates to the aforesaid combined preparation for use as a medicament and for use in the treatment of inappropriate cellular proliferation, preferably in the treatment of cancer. Moreover, the present invention relates to a method for determining whether a subject suffering from inappropriate cellular proliferation is amenable to a treatment comprising administration of a modulator of PKM2 activity as the only PKM2 inhibitor and to treatment methods related thereto.
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