IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS

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专利权人:

ALNYLAM PHARMACEUTICALS; INC.

发明人:

AKINC, AKIN,MAIER, MARTIN,KUMAR, VARUN

申请号：

CA2891911

公开号：

CA2891911A1

申请日:

2013.12.04

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA. In addition to the biodegradable cationic lipid the nanoparticles comprise a non-cationic lipid, polyethylne glycol dipalmitoylglycerol (PEG-DPG) and optionally a sterol.

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