Improved nucleic acid lipid particle formulations

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专利权人:

Alnylam Pharmaceuticals; Inc.

发明人:

Akinc, Akin,Maier, Martin,Kumar, Varun

申请号：

AU2013355258

公开号：

AU2013355258A1

申请日:

2013.12.04

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA. In addition to the biodegradable cationic lipid the nanoparticles comprise a non-cationic lipid, polyethylne glycol dipalmitoylglycerol (PEG-DPG) and optionally a sterol.

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