Mark Cameron,Jennifer R. Davis,Andrea R. Geiser,Matthew G. Stanton,Vladislav V. Telyatnikov,Lu Tian,Weimin Wang
申请号：
US13390702
公开号：
US09181295B2
申请日:
2010.08.18
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
