Zhiqiang Yang,Fengqi Zhang,Guizhen Dong,Sandra Lee Knowles,Milana Maletic
申请号：
US14912233
公开号：
US20160185764A1
申请日:
2014.08.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to bicyclic himbacine derivatives of the formulaor a pharmaceutically acceptable salt thereofwherein: R1 is —[C(Ra)(Rb)]x—[C(Rb)(Rb)]y—C(O)NH2, or —N(H)—[(CH2)]z—C(O)—NH2, W isand the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD.
