James Francis Dropinski,Milana Maletic,Jae-hun Kim,Deyou Sha
申请号：
US14912315
公开号：
US20160200713A1
申请日:
2014.08.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to bicyclic himbacine derivatives of the formulaor a pharmaceutically acceptable salt thereof wherein: R1 is halo —CN alkyl cycloalkyl alkoxy phenyl, which is optionally substituted one or twice independently by alkyl, halo, or —CN or a thiophene ring, which is optionally substituted once or twice independently by alkyl.The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD.
