PREPARATION AND USE OF 7A-HETEROCYCLE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR ANTAGONISTS
- 专利权人:
- Zhiqiang YANG
- 发明人:
- Zhiqiang Yang,Guizhen Dong,Milana Maletic
- 申请号:
- US14912212
- 公开号:
- US20160200715A1
- 申请日:
- 2014.08.18
- 申请国别(地区):
- US
- 年份:
- 2016
- 代理人:
- 摘要:
- The present invention relates to bicyclic himbacine derivatives of the formulaor a pharmaceutically acceptable salt thereof wherein: R1 isW isand the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD.
- 来源网站:
- 中国工程科技知识中心
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