NURIA BUSQUETS BAQUE SPAIN,FRANCESCA PAJUELO LORENZO SPAIN
申请号：
IN10018/DELNP/2008
公开号：
IN301315B
申请日:
2007.07.16
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
This invention is directed to a process for manufacturing 3(R)-(2-hydroxy-2,2- dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo 2.2.2 octane bromide by reacting 2-hydroxy-2,2-dithien-2-ylacetic acid 1 -azabicyclo 2.2.2 oct-3(R)yl ester and 3-phenoxypropyl bromide, wherein the reaction takes place in a solvent or mixtures of solvents having a boiling point between 50 and 210°C and selected from the group consisting of ketones and cyclic ethers. WO2008009397A1
