#$%^&*AU2020217419A120200917.pdf#####Abstract. The present application is directed to storage-stable composition comprising a silk fibroin matrix and an active agent that is distributed and embedded therein. Bioactivity of the active agent is maintained after freeze-thaw cycles, or for at least 24 hours at °C. Active agents are immunogens such as peptides, vaccines, nucleic acids, viruses or bacteria, or are small molecules, antibiotics, vectors or anti-venom for example. The silk fibroin is preferably dried by lyophilisation to form a solid state silk fibroin. Also defined are kits and devices such as nasal sprays, syringes and dry powder injectors comprising this composition. These compositions are formulated to stabilise the active agent within the silk fibroin matrix, in particular, vaccine stabilisation.WO 2012/145739 PCT/US2012/034643 12/22 I I AMI ivni % M1dICI3 CCIA o - --- -----(AON31Od IVOOISIH (%A33IOd 1VOWIS]N Cl T7" l IrIPTT PT ClT T7 T7IP T-')T Tr T
