This disclosure provides compositions and methods for enhancing innate immune system activities and responses by combining lunasin with at least one cytokine. The compositions synergistically enhance the effect of these selected cytokine(s), including but not limited to, activating Natural Killer (NK) cells, augmenting NK's cytotoxicity against viruses and tumors, regulating NK mediated anti-allergic inflammation, producing potent NK cells for cellular therapy using adoptive transfer. and facilitating dendritic cells antigen presentation.
