Steven M. Albelda,Liang-Chuan Wang,Andrew Wells,Shaun OBrien
申请号：
US14772617
公开号：
US20160017286A1
申请日:
2014.03.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides compositions and methods for inhibiting Ikaros in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of Ikaros in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
