РАБУКА Дэвид (US),ХОЛГЕЙТ Роберт Джордж Эдвард (GB),КАРР Френсис Джозеф (GB)
申请号：
RU2015105588
公开号：
RU2015105588A
申请日:
2013.07.15
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An antibody that specifically binds to an epitope of CD22, wherein said antibody comprises: a) an immunoglobulin heavy chain comprising a VH domain with aminokislotEVQLVESGGGLVKPGGSLX1LSCAASGFAFSIYDMSWVRQAPGKGLEWVAYISSGGGTTYYPDTVKGRFTISRDNAKNX2LYLQMX3SLRAEDTAMYYCARHSGYGSSYGVLFAYWGQGTLVTVSS sequence (SEQ ID NO: 1), where X b is K or R Hpredstavlyaet is S or T and Hpredstavlyaet an N or S and b) a light chain immunoglobulina.2. An antibody according to claim. 1, characterized in that said light chain comprises the sequence aminokislot3. An antibody according to claim. 1, characterized in that said light chain comprises the sequence aminokislot4. An antibody according to claim. 1, characterized in that said light chain comprises the sequence aminokislot5. An antibody that specifically binds to an epitope of CD22, wherein said antibody comprises: a) an immunoglobulin light chain comprising the sequence aminokislotgde X b is L (Leu) or V (Val) Hpredstavlyaet a V or P Hpredstavlyaet and a Q or P and b) a heavy chain immunoglobulina.6. An antibody according to claim 5, characterized in that said heavy tsepimmunoglobulina comprises an amino acid sequence selected from:. 7. An antibody according to any one of claims. 1-6, characterized in that said region of said light chain and heavy chain are present in separate polipeptidah.8. An antibody according to any one of claims. 1-6, characterized in that said region of said light chain and heavy chain are present in one polipeptide.9. An antibody according to any one of claims. 1-6, characterized in that said antibody binds said epitope with an affinity of between about 107 gsm to about 1012 M.10. An antibody according to any one of claims. 1-6, characterized in that the heavy chain belongs to isotype IgG1, IgG2, IgG3 or IgG4.11.1. Антитело, которое специфично связывает эпитоп в CD22, при этом указанное антитело содержит:a) тяжелую цепь иммуноглобулина, содержащую область VH с последовательностью аминокислотEVQLVESGGGLVKPGGSLX
