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COMPOSITIONS CONTAINING HUMANIZED ANTIBODIES TO CD19
专利权人:
ЭлЭлСи (US);МедИммьюн
发明人:
ШАРМА Моника (US),ШАХ Амбариш (US)
申请号:
RU2011140486/15
公开号:
RU2011140486A
申请日:
2010.03.08
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A sterile, stable aqueous composition comprising a chimeric, humanized or human anti-CD19.2 antibody. The composition of claim 1, wherein said antibody has not been lyophilized. The composition of claim 1, wherein said antibody is from the class of immunoglobulins and is selected from the group consisting of IgA, IgE, IgM, IgD, IgY, and IgG. The composition of claim 1, wherein said antibody is IgG1, IgG2, IgG3 or IgG4 (human isotype). The composition of claim 1, wherein the antibody comprises an Fc region having N-glycoside-linked sugar chains in which fucose is not linked to N-acetylglucosamine at the reducing end of the sugar chain. A composition according to any one of claims 1 to 5, wherein said antibody comprises a heavy chain variable region comprising the sequence of SEQ ID NO: 104.7. A composition according to any one of claims 1 to 5, wherein said antibody comprises a light chain variable region comprising the sequence of SEQ ID NO: 111.8. A composition according to any one of claims 1 to 5, wherein said antibody comprises a heavy chain variable region comprising the sequence of SEQ ID NO: 104, and a light chain variable region comprising the sequence of SEQ ID NO: 111.9. The composition according to any one of claims 1 to 5, wherein said antibody comprises a heavy chain variable region comprising the sequence of SEQ ID NO: 104, and a light chain variable region comprising the sequence of SEQ ID NO: 111, as well as an Fc region having N- glycoside-linked chains of complex Sugars in which fucose is not bound to N-acetylglucosamine at the reducing end of the sugar chain. 10. The composition of claim 1, wherein the concentration of said antibody is at least about 5 mg / ml, at least1. Стерильная, устойчивая водная композиция, содержащая химерное, гуманизированное или человеческое антитело к CD19.2. Композиция по п.1, в которой указанное антитело не было подвергнуто лиофилизации.3. Композиция по п.1, в которой указанное антитело - из класса иммуноглобулинов
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