1. An isolated antibody that binds to angiopoietin-2 (Ang-2), the antibody comprising the variable region of the light chain:! a) SEQ ID No: 3 (MEDI1)； ! b) SEQ ID No: 4 (MEDI2)； ! c) SEQ ID No: 5 (MEDI3)； ! d) SEQ ID No: 6 (MEDI4)； or! e) SEQ ID No: 8 (MEDI6). ! 2. The antibody according to claim 1, wherein the antibody comprises a light chain variable region of SEQ ID No: 3 (MEDI1). ! 3. The antibody according to claim 1, wherein the antibody is produced with high efficiency in mammalian host cells, which is equal to or 2 times or more than the efficiency of producing antibodies against Ang-2 containing SEQ ID No: 1 and SEQ ID No: 2 ( 3.19.3). ! 4. The antibody according to claim 1, wherein the antibody exhibits an aggregation rate that is at least 10% lower than the aggregation rate of an anti-Ang-2 antibody containing SEQ ID No: 1 and SEQ ID No: 2 (3.19.3), which was determined in similar conditions. ! 5. The antibody according to claim 1, wherein the antibody further includes a heavy chain variable region of SEQ ID No: 7 (MEDI5). ! 6. The antibody according to claim 1, wherein the antibody comprises the light chain variable region of SEQ ID No: 3 (MEDI1) and the heavy chain variable region of SEQ ID No: 7 (MEDI5). ! 7. The antibody according to claim 6, wherein the antibody exhibits a melting point that is higher than the melting temperature of an anti-Ang-2 antibody containing SEQ ID No: 1 and SEQ ID No: 2 (3.19.3). ! 8. Isolated nucleic acid encoding at least one isolated antibody that binds to angiopoietin-2 (Ang-2), including the variable regions of the light and heavy chains of SEQ ID No: 3 (MEDI1) and SEQ ID No: 7 (MEDI5) . ! 9. A composition comprising:! a) an isolated antibody that binds to Ang-2, wherein the antibody comprises the light chain variable region of SEQ ID No: 3 (MEDI1) and the heavy chain variable region of SEQ ID No: 7 (MEDI5)； and! b) excipient,! for use in inhibiting angiogen�1. Выделенное антитело, которое связывается с ангиопоэтином-2
