PROBLEM TO BE SOLVED: To provide a composition comprising a human IgG1 (immunoglobulin G1) monoclonal antibody that specifically binds to human interleukin-1α.SOLUTION: According to the present invention, there are provided a human IgG1 (immunoglobulin G1) monoclonal antibody effective for killing cancer cells, and a composition comprising the same. Here, the monoclonal antibody comprises an antigen-binding variable region that exhibits very high binding affinity for human interleukin-1α and a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors. There is also provided a composition for inhibiting tumor cell cells into a basement membrane matrix. Here, the composition comprises a human IgGI monoclonal antibody that specifically binds to human interleukin 1α that inhibits increased expression of ICAM-1 and/or E-selectin in endothelial cells.SELECTED DRAWING: None【課題】ヒトインターロイキン１αに特異的に結合するヒトＩｇＧ１（免疫グロブリンＧ１）モノクローナル抗体を含む、組成物の提供。【解決手段】インターロイキン１αに対する非常に高い結合親和性を示す抗原結合可変領域と、Ｃ１ｑ結合を通じた補体系の活性化及びいくつかの異なるＦｃ受容体への結合のいずれにおいても有効な定常領域とを含み、癌細胞の殺傷に有効なヒトＩｇＧ１（免疫グロブリンＧ１）モノクローナル抗体、及びこれを含む組成物。基底膜マトリクスへの腫瘍細胞細胞の阻害組成物であり、更に内皮細胞内におけるＩＣＡＭ－１及び／又はＥ－セレクチン発現の増加を阻害するヒトインターロイキン１αに特異的に結合するヒトＩｇＧＩモノクローナル抗体を含む、組成物。【選択図】なし
